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Estimated glomerular filtration rates are higher when creatinine-based equations are compared with a cystatin C-based equation in coronavirus disease 2019

Anders O. Larsson (Författare), Michael Hultström, 1978- (Författare), Robert Frithiof (Författare), Miklós Lipcsey (Författare), Ulf Nyman (Författare), Mats B Eriksson (Författare)

URI http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-488640, URN urn:nbn:se:uu:diva-488640, DOI 10.1111/aas.14173, Identifikator http://uu.diva-portal.org/smash/get/diva2:1712085/FULLTEXT01 · url

Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (Utgivare), Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (Utgivare), Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (Utgivare), Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (Utgivare)

utgivning

John Wiley & Sons, 2023

är del av

Acta Anaesthesiologica Scandinavica · ISSN 0001-5172

67:2, 213-220

Bidrag, Onlineresurs

Finns online:

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-488640

ämne

Medical and Health Sciences, Clinical Medicine, Anesthesiology and Intensive Care, Medicin och hälsovetenskap, Klinisk medicin, Anestesi och intensivvård

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Sammanfattning

OBJECTIVES: Estimations of glomerular filtration rate (eGFR) are based on analyses of creatinine and cystatin C, respectively. Covid-19 patients in the intensive care unit (ICU) often have acute kidney injury and are at increased risk of drug induced kidney injury. The aim of this study was to compare creatinine-based eGFR equations to cystatin C-based eGFR in ICU patients with COVID-19. METHODS: After informed consent, we included 370 adult ICU patients with COVID-19. Creatinine and cystatin C were analyzed at admission to the ICU as part of the routine care. Creatinine-based eGFR (mL/min) was calculated using following equations, developed in chronological order; the Cockcroft-Gault (C-G), MDRD 1999, MDRD 2006, CKD-EPI and LMR equations, which were compared with eGFR calculated using the cystatin C-based CAPA equation. RESULTS: The median eGFR when determined by C-G was 99 mL/min and interquartile range (IQR: 67 mL/min). Corresponding estimations for MDRD1999 were 90 mL/min (IQR: 54); MDRD2006: 85 mL/min (IQR: 51); CKD-EPI: 91 mL/min (IQR: 47); and for LMR 83 mL/min (IQR: 41). eGFR calculated using cystatin C and the CAPA equation values was 70 mL/min (IQR: 38). All differences between creatinine based eGFR versus cystatin C based eGFR were significant (p<0.00001). CONCLUSIONS: Estimation of GFR based on various analyses of creatinine are higher when compared to a cystatin C-based equation. The C-G equation had the worst performance and should not be used in combination with modern creatinine analysis methods for determination of drug dosage in COVID-19 patients.

Detaljer

Medverkan och funktion

Anders O. Larsson (Författare), Michael Hultström, 1978- (Författare), Robert Frithiof (Författare), Miklós Lipcsey (Författare), Ulf Nyman (Författare), Mats B Eriksson (Författare)

Medverkan och funktion

Identifikator

URI http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-488640, URN urn:nbn:se:uu:diva-488640, DOI 10.1111/aas.14173, Identifikator http://uu.diva-portal.org/smash/get/diva2:1712085/FULLTEXT01 · url

har titel

Estimated glomerular filtration rates are higher when creatinine-based equations are compared with a cystatin C-based equation in coronavirus disease 2019