Plasma soluble Urokinase-Type Plasminogen activator receptor is not associated with neurological Outcome in Patients with aneurysmal subarachnoid hemorrhage [Elektronisk resurs]
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Kiiski, Heikki (författare)
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Jalkanen, Ville (författare)
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Ala-Peijari, Marika (författare)
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Hamalainen, Mari (författare)
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Moilanen, Eeva (författare)
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Peltola, Jukka (författare)
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Tenhunen, Jyrki (författare)
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Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (utgivare)
- FRONTIERS MEDIA SA 2017
- Engelska.
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Ingår i: Frontiers in Neurology. - 1664-2295. ; 8
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- Object: Aneurysmal subarachnoid hemorrhage (aSAH) is a common cause of death or long-term disability. Despite advances in neurocritical care, there is still only a very limited ability to monitor the development of secondary brain injury or to predict neurological outcome after aSAH. Soluble urokinase-type plasminogen activator receptor (suPAR) has shown potential as a prognostic and as an inflammatory biomarker in a wide range of critical illnesses since it displays an association with overall immune system activation. This is the first time that suPAR has been evaluated as a prognostic biomarker in aSAH. Methods: In this prospective population-based study, plasma suPAR levels were measured in aSAH patients (n = 47) for up to 5 days. suPAR was measured at 0, 12, and 24 h after patient admission to the intensive care unit (ICU) and daily thereafter until he/ she was transferred from the ICU. The patients' neurological outcome was evaluated with the modified Rankin Scale (mRS) at 6 months after aSAH. Results: suPAR levels (n = 47) during the first 24 h after aSAH were comparable in groups with a favorable (mRS 0-2) or an unfavorable (mRS 3-6) outcome. suPAR levels during the first 24 h were not associated with the findings in the primary brain CT, with acute hydrocephalus, or with antimicrobial medication use during 5-days' follow-up. suPAR levels were associated with generally accepted inflammatory biomarkers (C-reactive protein, leukocyte count). Conclusion: Plasma suPAR level was not associated with either neurological outcome or selected clinical conditions. While suPAR is a promising biomarker for prognostication in several conditions requiring intensive care, it did not reveal any value as a prognostic biomarker after aSAH.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Anesthesiology and Intensive Care (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Anestesi och intensivvård (hsv)
- Neurology (hsv)
- Neurologi (hsv)
Indexterm och SAB-rubrik
- aneurysmal subarachnoid hemorrhage
- biomarkers
- neurological outcome
- secondary brain injury
- soluble urokinase-type plasminogen activator receptor
- neuroinflammation
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