Elevated concentrations of serum matrix metalloproteinase-2 and -9 and their associations with circulating markers of cardiovascular diseases in chronic arsenic-exposed individuals [Elektronisk resurs]
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Islam, Md Shofikul (författare)
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Mohanto, Nayan Chandra (författare)
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Karim, Md Rezaul (författare)
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Aktar, Sharmin (författare)
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Hoque, Md Mominul (författare)
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Rahman, Atiqur (författare)
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Jahan, Momotaj (författare)
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Khatun, Rabeya (författare)
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Aziz, Abdul (författare)
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Abdus Salam, Kazi (författare)
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Saud, Zahangir Alam (författare)
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Hossain, Mostaque (författare)
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Rahman, Aminur 1984- (författare)
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Mandal, Abul (författare)
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Haque, Azizul (författare)
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Miyataka, Hideki (författare)
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Himeno, Seiichiro (författare)
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Hossain, Khaled (författare)
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Högskolan i Skövde Institutionen för biovetenskap (utgivare)
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Högskolan i Skövde Forskningscentrum för Systembiologi (utgivare)
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bioteknik (medarbetare)
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bioteknik (medarbetare)
- BioMed Central 2015
- Engelska.
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Ingår i: Environmental health. - 1476-069X. ; 14 1
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- Background: Cardiovascular diseases (CVDs) and cancers are the major causes of chronic arsenic exposure-related morbidity and mortality. Matrix metalloproteinase-2 (MMP-2) and −9 (MMP-9) are deeply involved in the pathogenesis of CVDs and cancers. This study has been designed to evaluate the interactions of arsenic exposure with serum MMP-2 and MMP-9 concentrations especially in relation to the circulating biomarkers of CVDs. Methods: A total of 373 human subjects, 265 from arsenic-endemic and 108 from non-endemic areas in Bangladesh were recruited for this study. Arsenic concentrations in the specimens were measured by inductively coupled plasma mass spectroscopy (ICP-MS) and serum MMPs were quantified by immunoassay kits. Results: Serum MMP-2 and MMP-9 concentrations in arsenic-endemic population were significantly (p < 0.001) higher than those in non-endemic population. Both MMPs showed significant positive interactions with drinking water (rs = 0.208, p < 0.001 for MMP-2; rs = 0.163, p <0.01 for MMP-9), hair (rs= 0.163, p < 0.01 for MMP-2; rs = 0.173, p < 0.01 for MMP-9) and nail (rs= 0.160, p < 0.01 for MMP-2; rs = 0.182, p < 0.001 for MMP-9) arsenic of the study subjects. MMP-2 concentrations were 1.02, 1.03 and 1.05 times, and MMP-9 concentrations were 1.03, 1.06 and 1.07 times greater for 1 unit increase in log-transformed water, hair and nail arsenic concentrations, respectively, after adjusting for covariates (age, sex, BMI, smoking habit and hypertension). Furthermore, both MMPs were increased dose-dependently when the study subjects were split into three (≤10, 10.1-50 and > 50 μg/L) groups based on the regulatory upper limit of water arsenic concentration set by WHO and Bangladesh Government. MMPs were also found to be significantly (p < 0.05) associated with each other. Finally, the concentrations of both MMPs were correlated with several circulating markers related to CVDs. Conclusions: This study showed the significant positive associations and dose–response relationships of arsenic exposure with serum MMP-2 and MMP-9 concentrations. This study also showed the interactions of MMP-2 and MMP-9 concentrations with the circulating markers of CVDs suggesting the MMP-2 and MMP-9 -mediated mechanism of arsenic-induced CVDs.
Ämnesord
- Natural Sciences (hsv)
- Biological Sciences (hsv)
- Biochemistry and Molecular Biology (hsv)
- Naturvetenskap (hsv)
- Biologiska vetenskaper (hsv)
- Biokemi och molekylärbiologi (hsv)
- Natural sciences (his)
- Naturvetenskap (his)
Indexterm och SAB-rubrik
- Arsenic
- MMP-2
- MMP-9
- Cardiovascular diseases
- Cancer
- Bangladesh
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