Inflammatory patterns in fixed airflow obstruction are dependent on the presence of asthma [Elektronisk resurs]
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Mogensen, Ida (författare)
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Jacinto, Tiago (författare)
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Alving, Kjell, 1959- (författare)
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Fonseca, João A. (författare)
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Jansson, Christer (författare)
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Malinovschi, Andrei, 1978- (författare)
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Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (utgivare)
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Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (utgivare)
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Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (utgivare)
- Publicerad: PUBLIC LIBRARY SCIENCE, 2020
- Engelska.
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Ingår i: PLoS ONE. ; 15:12
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Sammanfattning
Ämnesord
Stäng
- Rationale: Fixed airflow obstruction (FAO) can complicate asthma. Inflammation is a proposed underlying mechanism. Objective: Our aim in this cross-sectional investigation was to evaluate the blood leucocyte pattern and level of exhaled nitric oxide in asthmatics and non-asthmatics with or without FAO. Methods: A total of 11,579 individuals aged >= 20 years from the US National Health and Nutrition Examination Survey were included. They were grouped as: controls without asthma and FAO (n = 9,935), asthmatics without FAO (n = 674), asthmatics with FAO (n = 180) and non-asthmatics with FAO (n = 790). FAO was defined as post-bronchodilator FEV1/FVC < lower limit of normal. Exhaled nitric oxide >= 25ppb, blood eosinophil levels >= 300 cells/mu L, and blood neutrophil levels >= 5100 cells/mu L were defined as elevated. Stratified analyses for smoking and smoking history were performed. Results: Elevated blood eosinophil levels were more common in all groups compared to the controls, with the highest prevalence in the group with asthma and fixed airflow obstruction (p<0.01). In a multiple logistic regression model adjusted for potential confounders including smoking, the asthma groups had significantly higher odds ratios for elevated B-Eos levels compared to the control group (odds ratio 1.4, (confidence interval: 1.1-1.7) for the asthma group without fixed airflow obstruction and 2.5 (1.4-4.2) for the asthma group with fixed airflow obstruction). The group with fixed airflow obstruction without asthma had higher odds ratio for elevated blood neutrophil levels compared to the controls: 1.4 (1.1-1.8). Smoking and a history of smoking were associated to elevated B-Neu levels. Conclusion: Fixed airflow obstruction in asthma was associated with elevated blood eosinophil levels, whereas fixed airflow obstruction without asthma was associated with elevated blood neutrophil levels.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Respiratory Medicine and Allergy (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Lungmedicin och allergi (hsv)
Genre
- government publication (marcgt)
Indexterm och SAB-rubrik
- Eosinophil
- FeNO
- neutrophil
- asthma
- fixed airflow obstruction
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