Protein alterations in women with chronic widespread pain [Elektronisk resurs] An explorative proteomic study of the trapezius muscle
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Olausson, Patrik (författare)
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Gerdle, Björn (författare)
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Ghafouri, Nazdar (författare)
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Sjöström, Dick (författare)
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Blixt, Emelie (författare)
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Ghafouri, Bijar (författare)
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- Linköpings universitet Institutionen för medicin och hälsa (utgivare)
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Alternativt namn: IMH
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Alternativt namn: Engelska: Linköping Universty. Department of Medical and Health Sciences
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Alternativt namn: Linköping Universty. Department of Medicine and Health Sciences
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Se även: Linköpings universitet. Institutionen för hälsa och samhälle
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Se även: Linköpings universitet. Institutionen för medicin och vård
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Linköpings universitet Medicinska fakulteten (utgivare)
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Region Östergötland Sinnescentrum (utgivare)
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- Linköpings universitet Institutionen för klinisk och experimentell medicin (utgivare)
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Alternativt namn: IKE
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Alternativt namn: Linköping University. Department of Clinical and Experimental Medicine
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Alternativt namn: Linköping University. Faculty of Health Sciences. Department of Clinical and Experimental Medicine
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Region Östergötland Hjärt- och Medicincentrum (utgivare)
- Nature Publishing Group: Open Access Journals - Option C / Nature Publishing Group 2015
- Engelska.
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Ingår i: Scientific Reports. - 2045-2322. ; 5:11894
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- Chronic widespread pain (CWP) has a high prevalence in the population and is associated with prominent negative individual and societal consequences. There is no clear consensus concerning the etiology behind CWP although alterations in the central processing of nociception maintained by peripheral nociceptive input has been suggested. Here, we use proteomics to study protein changes in trapezius muscle from 18 female patients diagnosed with CWP compared to 19 healthy female subjects. The 2-dimensional gel electrophoresis (2-DE) in combination with multivariate statistical analyses revealed 17 proteins to be differently expressed between the two groups. Proteins were identified by mass spectrometry. Many of the proteins are important enzymes in metabolic pathways like the glycolysis and gluconeogenesis. Other proteins are associated with muscle damage, muscle recovery, stress and inflammation. The altered expressed levels of these proteins suggest abnormalities and metabolic changes in the myalgic trapezius muscle in CWP. Taken together, this study gives further support that peripheral factors may be of importance in maintaining CWP.
Ämnesord
- Medical and Health Sciences (hsv)
- Basic Medicine (hsv)
- Medicin och hälsovetenskap (hsv)
- Medicinska grundvetenskaper (hsv)
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