Simple cardiovascular risk stratification by replacing total serum cholesterol with anthropometric measures [Elektronisk resurs] The MORGAM prospective cohort project
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Rosberg, Victoria (författare)
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Vishram-Nielsen, Julie KK (författare)
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Kristensen, Anna M. Dyrvig (författare)
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Pareek, Manan (författare)
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Sehested, Thomas S.G. (författare)
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Nilsson, Peter M (författare)
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Linneberg, Allan (författare)
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Palmieri, Luigi (författare)
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Giampaoli, Simona (författare)
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Donfrancesco, Chiara (författare)
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Kee, Frank (författare)
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Mancia, Giuseppe (författare)
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Cesana, Giancarlo (författare)
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Veronesi, Giovanni (författare)
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Grassi, Guido (författare)
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Kuulasmaa, Kari (författare)
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Salomaa, Veikko (författare)
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Palosaari, Tarja (författare)
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Sans, Susana (författare)
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Ferrieres, Jean (författare)
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Dallongeville, Jean (författare)
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Söderberg, Stefan (författare)
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Moitry, Marie (författare)
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Drygas, Wojciech (författare)
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Tamosiunas, Abdonas (författare)
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Peters, Annette (författare)
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Brenner, Hermann (författare)
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Schöttker, Ben (författare)
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Grimsgaard, Sameline (författare)
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Biering-Sørensen, Tor (författare)
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Olsen, Michael H (författare)
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Umeå universitet Medicinska fakulteten (utgivare)
- Publicerad: Elsevier, 2022
- Engelska.
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Ingår i: Preventive Medicine Reports. ; 26
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- Relaterad länk:
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http://www.umu.se/ (Värdpublikation)
Sammanfattning
Ämnesord
Stäng
- To assess whether anthropometric measures (body mass index [BMI], waist-hip ratio [WHR], and estimated fat mass [EFM]) are independently associated with major adverse cardiovascular events (MACE), and to assess their added prognostic value compared with serum total-cholesterol. The study population comprised 109,509 individuals (53% men) from the MORGAM-Project, aged 19–97 years, without established cardiovascular disease, and not on antihypertensive treatment. While BMI was reported in all, WHR and EFM were reported in ∼52,000 participants. Prognostic importance of anthropometric measurements and total-cholesterol was evaluated using adjusted Cox proportional-hazards regression, logistic regression, area under the receiver-operating-characteristic curve (AUCROC), and net reclassification improvement (NRI). The primary endpoint was MACE, a composite of stroke, myocardial infarction, or death from coronary heart disease. Age interacted significantly with anthropometric measures and total-cholesterol on MACE (P ≤ 0.003), and therefore age-stratified analyses (<50 versus ≥ 50 years) were performed. BMI, WHR, EFM, and total-cholesterol were independently associated with MACE (P ≤ 0.003) and resulted in significantly positive NRI when added to age, sex, smoking status, and systolic blood pressure. Only total-cholesterol increased discrimination ability (AUCROC difference; P < 0.001). In subjects < 50 years, the prediction model with total-cholesterol was superior to the model including BMI, but not superior to models containing WHR or EFM, while in those ≥ 50 years, the model with total-cholesterol was superior to all models containing anthropometric variables, whether assessed individually or combined. We found a potential role for replacing total-cholesterol with anthropometric measures for MACE-prediction among individuals < 50 years when laboratory measurements are unavailable, but not among those ≥ 50 years.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Cardiac and Cardiovascular Systems (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Kardiologi (hsv)
Genre
- government publication (marcgt)
Indexterm och SAB-rubrik
- Adipose tissue
- Assessment
- risk
- Body mass index
- Cardiovascular diseases
- Cholesterol
- Waist-hip ratio
Inställningar
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Preventive Medicine Reports