NMR Spectroscopy in Pharmaceutical Analysis [Elektronisk resurs] / edited by Ulrike Holzgrabe, Iwona Wawer, Bernd Diehl.
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Holzgrabe, Ulrike (redaktör/utgivare)
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Wawer, Iwona (redaktör/utgivare)
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Diehl, Bernd (redaktör/utgivare)
- ISBN 9780080558196
- Publicerad: Oxford : Elsevier, 2008
- Engelska online resource (xxi, 501 s.)
- Relaterad länk:
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http://www.sciencedi... (Table of contents)
Innehållsförteckning
Sammanfattning
Ämnesord
Stäng
- Part I: Fundamentals and Techniques -- 1. Principles in NMR Spectroscopy / B. Diehl -- 2. Quantitative NMR in the Solution State NMR / F. Malz -- 3. qNMR in Solid State / I. Wawer -- 4. Microcoil Nuclear Magnetic Resonance Spectroscopy / A.G. Webb -- 5. qNMR Spectroscopy in Drug Analysis: A General View / U. Holzgrabe -- Part II: General Applications -- 1. Investigation of Multi-Component Drugs by NMR Spectroscopy / T. Beyer, U. Holzgrabe -- 2. NMR Applications for Polymer Characterisation / B. Diehl -- 3. NMR Spectroscopy of Natural Substances / B. Diehl -- 4. Solid-State Measurements of Drugs and Drug Formulations / I. Wawer -- 5. Metabolic Profiling / K.A. Kaiser, C.E. Merrywell, F. Fang, C.K. Larive -- 6. DOSY NMR for Drug Analysis / V. Gilard, S. Trefi, S. Balayssac, M.-A. Delsuc, T. Gostan, M. Malet-Martino, R. Martino, Y. Prigent, F. Taulelle -- 7. The Use of qNMR for the Analysis of Agrochemicals / R.J. Wells, J. Cheung, J.M. Hook -- Part III: Special Applications -- 1. NMR-Based Mixture Analysis on the Example of Fruit Juice Quality Control Using Statistics and Quantification / M. Spraul, E. Humpfer, H. Schäfer, B. Schütz, M. Mörtter, P. Rinke -- 2. NMR Assays for Carbohydrate-Based Vaccines / C. Jones, N. Ravenscroft -- 3. Fluorine-19 or Phosphorus-31 NMR Spectroscopy: A Powerful Technique for Biofluid Metabolic Studies and Pharmaceutical Formulation Analysis of Fluorinated or Phosphorylated Drugs / R. Martino, V. Gilard, M. Malet-Martino -- 4. Quantitative 2D NMR Analysis of Glycosaminoglycans / G. Torri, M. Guerrini -- 5. The Use of Proton NMR as an Alternative for the Amino Acid Analysis as Identity Test for Peptides / E. Kellenbach, K. Sanders, P.L.A. Overbeeke -- 6. Assessment of the Inhibitory Potency of Antibiotics by MRI / C. Faber -- 7. Hypernation and Concatenation: Multiple On-Line Spectroscopic Analysis for Drug and Natural Product Characterisation / I.D. Wilson -- 8. Quantitative High-Resolution Online NMR Spectroscopy in Pharmaceutical Reaction and Process Monitoring / M. Maiwald, O. Steinhof, C. Sleigh, M. Bernstein, H. Hasse.
- For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems often resulting in insufficient methods. Nevertheless such methods find their way into international pharmacopoeias. Thus, the aim of the book is to describe the possibilities of qNMR in pharmaceutical analysis. Beside the introduction to the physical fundamentals and techniques the principles of the application in drug analysis are described: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds, metabolism, and solid phase NMR spectroscopy for the characterization drug substances, e.g. the water content, polymorphism, and drug formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples. They give more detailed information by means of concrete examples.
Ämnesord
- Spektroskopi (sao)
- Nuclear magnetic resonance spectroscopy. (LCSH)
- Spectrum analysis (LCSH)
- Drugs -- Analysis. (LCSH)
- Spectrum analysis (LCSH)
Indexterm och SAB-rubrik
- Ucef Analytisk kemi
Klassifikation
- 615.1901 (DDC)
- Ucef (kssb/8)
Inställningar
Hjälp
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