A randomized, double-blind, placebo-controlled trial of camicinal in Parkinson's disease. [Elektronisk resurs]
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Marrinan, Sarah L (författare)
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Otiker, Tal (författare)
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Vasist, Lakshmi S (författare)
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Gibson, Rachel A (författare)
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Sarai, Bhopinder K (författare)
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Barton, Matthew E (författare)
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Richards, Duncan B (författare)
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Hellström, Per M. 1954- (författare)
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Nyholm, Dag (författare)
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Dukes, George E (författare)
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Burn, David J (författare)
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Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (utgivare)
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Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (utgivare)
- 2018
- Engelska.
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Ingår i: Movement Disorders. - 0885-3185. ; 33:2, 329-332
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Sammanfattning
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- BACKGROUND: Delayed gastric emptying may impair l-dopa absorption, contributing to motor fluctuations. We evaluated the effect of camicinal (GSK962040), a gastroprokinetic, on the absorption of l-dopa and symptoms of PD. METHODS: Phase II, double-blind, placebo-controlled trial. Participants were randomized to receive camicinal 50 mg once-daily (n = 38) or placebo (n = 20) for 7 to 9 days. RESULTS: l-dopa exposure was similar with coadministration of camicinal compared to placebo. Median time to maximum l-dopa concentration was reduced, indicating more rapid absorption of l-dopa. Camicinal resulted in significant reduction in OFF time (-2.31 hours; 95% confidence interval: -3.71, -0.90), significant increase in ON time (+1.88 hours; 95% confidence interval: 0.28, 3.48) per day, and significant decrease in mean total MDS-UPDRS score (-12.5; 95% confidence interval: -19.67, -5.29). Camicinal treatment was generally well tolerated. CONCLUSIONS: PD symptom improvement with camicinal occurred in parallel with more rapid absorption of l-dopa. This study provides evidence of an improvement of the motor response to l-dopa in people with PD treated with camicinal 50 mg once-daily compared with placebo, which will require further evaluation.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Neurology (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Neurologi (hsv)
Indexterm och SAB-rubrik
- Clinical trials Randomized controlled (CONSORT agreement)
- Parkinson's disease/parkinsonism
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