Restoration of MPTP-induced deficits by exercise and Milmed (R) co-treatment [Elektronisk resurs]
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Archer, Trevor (författare)
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Garcia, Danilo (författare)
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Fredriksson, Anders (författare)
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Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (utgivare)
- 2014
- Engelska.
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Ingår i: PeerJ. - 2167-8359. ; 2, e531
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Sammanfattning
Ämnesord
Stäng
- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces permanent neurochemical and functional deficits. Following the administration of either two or four injections of the dopamine neurotoxin, MPTP, at a dose of 40 mg/kg, C57/BL6 mice were given access to running-wheels (30-min sessions, four times/week, Monday-Thursday) and treatment with the treated yeast, Milmed (R) (four times/week, Monday-Thursday), or simply running-wheel exercise by itself, over ten weeks. It was observed that the combination of physical exercise and Milmed (R) treatment, the MPTP + Exercise + Yeast (MC) group [MPTP + Exercise + Milmed (R) (MC)], restored spontaneous motor activity markedly by test day 10, restored completely subthreshold L-Dopa-induced activity, and dopamine concentration to 76% of control values, in the condition wherein two administrations of MPTP (2 x 40 mg/kg) were given prior to initiation of exercise and/or Milmed (R) treatment. Physical exercise by itself, MPTP + Exercise (MC) group, attenuated these deficits only partially. Administration of MPTP four times (i.e., 40 mg/kg, s.c., once weekly over four weeks for a total of 160 mg/kg, MPTP + Exercise + Yeast (MC) group [MPTP + Exercise + Milmed (R) (SC)] and MPTP + Exercise (SC), induced a lesioning effect that was far too severe for either exercise alone or the exercise + Milmed (R) combination to ameliorate. Nevertheless, these findings indicate a powerful effect of physical exercise reinforced by Milmed (R) treatment in restoring MPTP-induced deficits of motor function and dopamine neurochemistry in mice.
Ämnesord
- Medical and Health Sciences (hsv)
- Basic Medicine (hsv)
- Neurosciences (hsv)
- Medicin och hälsovetenskap (hsv)
- Medicinska grundvetenskaper (hsv)
- Neurovetenskaper (hsv)
Indexterm och SAB-rubrik
- MPTP
- Exercise
- Milmed (R)
- Parkinsonism
- Running-wheels
- Locomotion
- Total activity
- Dopamine
- Attenuation
- Restoration
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