Obesity attenuates gender differences in cardiovascular mortality [Elektronisk resurs]
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Song, Xin (författare)
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Tabak, Adam G. (författare)
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Zethelius, Björn (författare)
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Yudkin, John S. (författare)
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Söderberg, Stefan (författare)
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Laatikainen, Tiina (författare)
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Stehouwer, Coen D. A. (författare)
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Dankner, Rachel (författare)
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Jousilahti, Pekka (författare)
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Onat, Altan (författare)
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Nilsson, Peter M. (författare)
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Satman, Ilhan (författare)
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Vaccaro, Olga (författare)
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Tuomilehto, Jaakko (författare)
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Qiao, Qing (författare)
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- Umeå universitet Medicinska fakulteten (utgivare)
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Alternativt namn: Umeå universitet. Medicinsk-odontologiska fakulteten
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Alternativt namn: Medicinska fakulteten vid Umeå universitet
- 2014
- Engelska.
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Ingår i: Cardiovascular Diabetology. - 1475-2840. ; 13
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Sammanfattning
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- Background: To estimate cardiovascular disease (CVD) mortality in relation to obesity and gender. Methods: Data from 11 prospective cohorts from four European countries including 23 629 men and 21 965 women, aged 24 to 99 years, with a median follow-up of 7.9 years were analyzed. Hazards ratios (HR) for CVD mortality in relation to baseline body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) were estimated using Cox proportional hazards models with age as the timescale. Results: Men had higher CVD mortality than women in all four BMI categories (<25.0, 25.0-29.9, 30.0-34.9 and >= 35.0 kg/m(2)). Compared with the lowest BMI category in women, multivariable adjusted HRs (95% confidence intervals) for higher BMI categories are 1.0 (0.8-1.4), 1.6 (1.1-2.1) and 2.8 (2.0-3.8) in women and 2.8 (2.2-3.6), 3.1 (2.5-3.9), 3.8 (2.9-4.9) and 5.4 (3.8-7.7) in men, respectively. Similar findings were observed for abdominal obesity defined by WC, WHR or WHtR. The gender difference was slightly smaller in obese than in non-obese individuals; but the interaction was statistically significant only between gender and WC (p = 0.02), and WHtR (p = 0.01). None of the interaction terms was significant among non-diabetic individuals. Conclusions: Men had higher CVD mortality than women across categories of anthropometric measures of obesity. The gender difference was attenuated in obese individuals, which warrants further investigation.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Cardiac and Cardiovascular Systems (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Kardiologi (hsv)
- Endocrinology and Diabetes (hsv)
- Endokrinologi och diabetes (hsv)
Indexterm och SAB-rubrik
- Obesity
- Gender
- Cardiovascular disease mortality
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