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Non-fiction literature, Text · English
Superantigens
B. Fleischer (Editor), H. O. Sjogren (Editor)
DOI 10.1007/978-3-642-50998-8, ISBN 3642509983
1st ed. 1991.
publication
Berlin, Heidelberg : Springer-Verlag, 1991, [1991]1 online resource (X, 137 p. 5 illus.)
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Current topics in microbiology and immunology · Current Topics in Microbiology and Immunology ; Volume 174Volume 174.edited by B. Fleischer and H.O. Sjogren
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Antigens.Has other physical format
Superantigens / · ISBN 3-642-51000-0 (Print:)Summary
This volume of Current Topics in Microbiology and Immunology is concerned with a class of molecules that are the most potent polyclonal stimulators of T lymphocytes of several species. These molecules have been named "superantigens" because they use a mechanism of T cell stimulation closely mimicking MHC-restricted recognition of specific antigen: they act on variable parts of T cell antigen receptors and are presented by MHC class II molecules. Prototypes of these molecules are the pyrogenic exotoxins produced by S. aureus and S. pyogenes, of which the staphylococcal enterotoxins and the toxic shock syndrome toxin are the best known. Superantigens also occur endogen ously in mice, most notably the enigmatic Mis determinants, that have withstood characterization for nearly 20 years. Only very recently was it found that Mis is probably encoded by endogenous retroviruses. The list of candidates that are implicated as being superantigens is growing. In many cases, however, the proof that a given molecule indeed falls into this category is still missing.
Table of Contents
Molecular Genetics of Pyrogenic Exotoxin “Superantigens” of Group A Streptococci and Staphylococcus aureus -- T Cell Recognition of Superantigens -- T Cell Activation by Superantigens—Dependence on MHC Class II Molecules -- The Human T Cell Response to Mitogenic Microbial Exotoxins -- Toxic Shock Syndrome Toxin-1, Toxic Shock, and the Immune System -- Staphylococcal Enterotoxin-Dependent Cell-Mediated Cytotoxicity -- CD4/CD8 Coreceptor-Independent Costimulator-Dependent Triggering of SEB-Reactive Murine T Cells -- The Immunobiology of Mycoplasma arthritidis and its Superantigen MAM -- The Anti-CD3-Induced Syndrome: A Consequence of Massive In Vivo Cell Activation.
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Contributor and role
B. Fleischer (Editor), H. O. Sjogren (Editor)Classification
616.0792 (DDC Classification)Identifier
DOI 10.1007/978-3-642-50998-8, ISBN 3642509983Indirectly identified by
ISBN 3642510000Title resource
SuperantigensCreative responsibility statement
edited by B. Fleischer and H.O. SjogrenEdition statement
1st ed. 1991.publication
Berlin, Heidelberg : Springer-Verlag, 1991, [1991]copyright
©1991Extent
1 online resource (X, 137 p. 5 illus.)Note
- Bibliographic Level Mode of Issuance: Monograph
- Includes bibliographical references at the end of each chapters and index.
Has other physical format
Superantigens / · ISBN 3-642-51000-0 (Print:)Series membership
Current topics in microbiology and immunology · Current Topics in Microbiology and Immunology ; Volume 174Volume 174.control number
16001486Resource ID / Permalink: https://libris.kb.se/j2v28h8v2d5pwtw#it
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