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Sökning: onr:dw0k2ckdbnsw94qc > Mucinous colorectal...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
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040 a Lib swee ie rda
041 a eng
100a Ganesan, Harsha4 aut
2451 0a Mucinous colorectal cancer oxidative stress and therapeutic MicroRNAs /c Harsha Ganesan, M. K. Makalakshmi, Antara Banerjee, Hong Zhang, Xiao-Feng Sun & Surajit Pathak.
264 1c 2022
336 a textb txt2 rdacontent
337 a computerb c2 rdamedia
338 a online resourceb cr2 rdacarrier
520 a Colorectal Cancer (CRC) is the third most leading cause of cancer related death worldwide and has a diverse clinical etiology. Mounting evidences has shown that CRC, in its rare yet lethal form as mucinous adenocarcinoma. Has led to poor prognosis and eventual complexity in the treatment. This subcategory of CRC characteristically secrete mucin hence, they are histologically identified based on the presence of mucin in CRC. In this context, the current article aims to provide a detailed overview and understanding of the underlying molecular mechanisms governing mucinous cancer onset and progression. We elaborate on the role of different pathways and molecular targets including microsatellite instability (MSI), chromosome instability (CIN) and CpG island methylator phenotype (CIMP), oncogenes such as KRAS, BRAF, p53 and p21 on mucinous CRC. The mucin genes, specifically MUC1, MUC4 and few other variants of the gel-secreted, transmembrane form of CRC play a vital role in the disease development. This makes the miRNA-mediated mucin regulations an exceptionally obliging aid in mucinous CRC understanding. The miRNAs discussed in context include miR-205, miR-373 and miR-124a to name a few. We further discuss the existing therapeutic strategies used to treat this variant of CRC. These diagnostic tools could help in the rapid identification and treatment of the disease.
700a Makalakshmi, M. K.4 aut
700a Banerjee, Antara4 aut
700a Zhang, Hong4 aut
700a Sun, Xiao-Feng,d 1959-4 aut0 https://libris.kb.se/6mk8q4s44v10ww9f#it
700a Pathak, Surajit4 aut
773t Handbook of Oxidative Stress in Cancer: Therapeutic Aspectsg Sidorna 1-18w 4l8f886x20mbpfkv
887 a {"@id":"dw0k2ckdbnsw94qc","modified":"2023-10-31T14:12:33.427+01:00"}2 librisxl
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Ingår i annan publikation. Gå till titeln Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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