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LIBRIS Formathandbok  (Information om MARC21)

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Fältnamn	Indikatorer	Metadata
000		02017naa a22002417i 4500
001		7p8b47qx57dv2cqt
003		SE-LIBR
005		20220929134740.0
007		cr ||| |||||
008		220929s2012 ne |||||o|||||000 ||eng|c
040		a Lib swee ie rda
041		a eng
100	1	a El-Serafi, Ahmed,d 1977-4 aut0 https://libris.kb.se/p4362k6zm4ktm2vz#it
245	1 0	a Epigenetic modifiers and stem cell differentiation /c Ahmed Taher El-Serafi.
264	1	c 2012
336		a textb txt2 rdacontent
337		a computerb c2 rdamedia
338		a online resourceb cr2 rdacarrier
520		a During stem cell differentiation, genes related to their unique characters should be silenced and genes related to the target lineage must be activated. Epigenetics is well known to control gene expression and changes of the epigenetic status during differentiation were reported. Epigenetic modifiers are chemical agents that can remove the epigenetic silencing markings and consequently activate the affected genes. The role of the epigenetic modifiers is well established in cancer treatment. Reports about enhancing stem cells differentiation (both murine and human) with treatment of the modifiers are accumulating. The modifiers have no differentiation ability by themselves but they enhance the differentiation upon culturing the cells in the corresponding conditions. This effect has been shown in monolayer culture as well as three-dimensional pellets. Epigenetic modifiers could be a valuable additive to the classical differentiation protocols, although various questions have yet to be answered including the safety of the agents.
773	0	a Hayat, M.At Stem Cells and Cancer Stem Cells, Volume 8 : Therapeutic Applications in Disease and Injuryg Sidorna 147-154w 19299799
887		a {"@id":"7p8b47qx57dv2cqt","modified":"2022-09-29T13:47:40.031+02:00"}2 librisxl
900	1 s	6 100a Serafi, Ahmed el-,d 1977-u El-Serafi, Ahmed,d 1977-
900	1 s	6 100a Elserafy, Ahmed,d 1977-u El-Serafi, Ahmed,d 1977-

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Ingår i annan publikation. Gå till titeln Hayat, M.A: Stem Cells and Cancer Stem Cells, Volume 8 : Therapeutic Applications in Disease and Injury

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