prefix : <https://id.kb.se/vocab/>
prefix owl: <http://www.w3.org/2002/07/owl#>
prefix librissearch: <https://id.kb.se/ns/librissearch/>
prefix ls: <https://id.kb.se/ns/librissearch/>
prefix xsd: <http://www.w3.org/2001/XMLSchema#>
prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#>
prefix jsonld: <http://www.w3.org/ns/json-ld#>
prefix bibdb: <https://id.kb.se/ns/bibdb/>
prefix fresnel: <http://www.w3.org/2004/09/fresnel#>
prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>
prefix marc: <https://id.kb.se/marc/>
prefix bulk: <https://id.kb.se/ns/bulk/>
prefix kbv: <https://id.kb.se/vocab/>
prefix sdo: <http://schema.org/>

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      :label "The perceived lack of drug discovery productivity in recent times has led to much debate in the pharmaceutical/biotechnology industry as escalating R&D costs are not being matched by increased output. Few observers doubt that selecting the right targets, ie those which are critical to disease pathology and are 'druggable', is the best starting point for improved productivity.The seven chapters of this volume describe recent progress towards drugs acting at a range of 'druggable' targets. One chapter addresses kinases, one covers an ion channel, two proteases are featured and three of t" ] ;
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      :label "Front cover; Title page; Copyright; Front matter; Preface; Table of contents; List of Contributors; Body; 1 Finding Protein Kinase Hits using Structural Information; Introduction; Screening by X-ray Crystallography; Screening by NMR; Fundamentals of NMR Spectroscopy; Using Chemical Shift Changes; Nuclear-Spin Relaxation; Nuclear Overhauser Effects; Exchange Phenomena; Applications of NMR in Screening; Target-Based Screening; Ligand-Based Screening; Examples of NMR Methods for Discovering Kinase Inhibitors; The Shapes Strategy; NMR Screening by Waterlogsy Method" ] ,
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      :label "NMR Screening of Protein Kinases by ATP-STD MethodNMR Backbone Assignment of a Kinase; Designing Novel Kinase Inhibitors from the NMR-Based Screening of Fragments; Design of Libraries for use in NMR Screening; In Silico Methods; Receptor-Based Screening; Compound Database and Receptor Preparation; Protein-Ligand Docking; Scoring Functions; Development and Evaluation of Docking and Scoring; Virtual Screening and Protein Kinases; Faults and Fixes for Virtual Screening; Consensus Scoring; Knowledge-Based Screening; Protein Flexibility and Induced Fit" ] ,
    [ a :TableOfContents ;
      :label "High Throughput Docking as a Virtual Screening ToolAlternatives to High Throughput Docking; Comparative Homology Modelling; De Novo Design; Summary; References; 2 Blunting the Swiss Army Knife of Hepatitis C Virus: Inhibitors of NS3/4A Protease; Hepatitis C Infection; Introduction; The Hepatitis C Virus; Current Therapies for the Treatment of HCV Infections; The HCV NS3/4A Protease; Tools to Study NS3/4A Protease Inhibitors; Enzymatic Assays; Viral Replication; Cell culture models; The replicon; Animal models; Resistance studies; Inhibitors of the NS3/4A Serine Protease" ] ,
    [ a :TableOfContents ;
      :label "Non-Covalent Peptidic InhibitorsCarboxylic acid containing inhibitors; BILN 2061; Phenethyl amide containing inhibitors; Non-covalent aza-peptide inhibitors; C-terminal acyl sulfonamide containing inhibitors; Prime-side inhibitors; Covalent Reversible Peptidic Inhibitors; Non-Peptidic Inhibitors; Summary and Outlook; References; 3 Peptide Deformylase Inhibitors; Introduction; Peptide Deformylase as a Novel Antibacterial Target; Function; Essentiality; Spectrum; Selectivity; Protein Structure of Peptide Deformylases; Three-Dimensional Structure; Metal-Binding Site; Fe2+-PDF" ] ,
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    marc:SerialsOriginalItemType ;
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<https://id.kb.se/term/saobf> a :ConceptScheme ;
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<https://id.kb.se/dataset/schemes> a :Dataset ;
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<https://id.kb.se/dataset/countries> a :Dataset ;
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  :mainEntity <https://id.kb.se/term/bibdb/univbib> ;
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<https://id.kb.se/term/rda/ComputerDiscCartridge> a :CarrierType ;
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<https://id.kb.se/term/rda/ComputerTapeReel> a :CarrierType ;
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  :inScheme <https://id.kb.se/term/rda> .

<https://libris.kb.se/qfv1qmh1s38fm0sx> a :Record ;
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<https://id.kb.se/term/rda/ComputerDisc> a :CarrierType ;
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<https://id.kb.se/term/rda/ComputerTapeCartridge> a :CarrierType ;
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<https://id.kb.se/term/rda/ComputerCard> a :CarrierType ;
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  :label "Computer card"@en , "Datorkort"@sv ;
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  :mainEntity <https://id.kb.se/term/saobf/ElectronicStorageMedium> ;
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<https://id.kb.se/term/saobf/ElectronicStorageMedium> a :CarrierForm ;
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<https://libris.kb.se/3s2630vd54gtmnp3> a :Record ;
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  :prefLabel "Serial publications"@en ;
  :singularLabel "Serial publication"@en , "Seriell publikation"@sv ;
  :searchLabel "Tidningar och periodika"@sv ;
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  :prefLabel "Hunting fiction"@en ;
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  :prefLabel "Essays"@en ;
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  :inScheme <https://id.kb.se/term/saogf> .

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