Regional differences in somatostatin receptor 2 (SSTR2) immunoreactivity is coupled to level of bowel invasion in small intestinal neuroendocrine tumors [Elektronisk resurs]
-
Fotouhi, Omid (författare)
-
Zedenius, Jan (författare)
-
Höög, Anders (författare)
-
Juhlin, Carl Christofer (författare)
-
Linköpings universitet Institutionen för klinisk och experimentell medicin (utgivare)
-
Linköpings universitet Medicinska fakulteten (utgivare)
-
Region Östergötland Diagnostikcentrum (utgivare)
- Publicerad: MAGHIRA & MAAS PUBLICATIONS, 2018
- Engelska.
-
Ingår i: Neuro - endocrinology letters. - 0172-780X. ; 39:4, 305-309
-
Läs hela texten
-
Läs hela texten
- Relaterad länk:
-
http://www.liu.se (Värdpublikation)
Sammanfattning
Ämnesord
Stäng
- OBJECTIVE: Somatostatin receptor (SSTR) expression constitutes a pivotal cornerstone for accurate radiological detection and medical treatment of small intestinal neuroendocrine tumors (SI-NETs), and the development of somatostatin analogues for these purposes have revolutionized the clinical work-up. Previous assessments of SSTR isoform expression in SI-NETs have found correlations to overall prognosis and treatment response, however these analyses usually report overall tumoral immunoreactivity, and little is reported regarding histo-regional differences in expressional patterns. METHODS: Thirty-seven primary SI-NETs (WHO grade I, n=32 and WHO grade II, n=5) were collected and assessed for SSTR2 immunohistochemistry. Samples were stratified with regards to histological level of bowel infiltration and spread (mucosal region, muscularis propria region, subserosal region) and each of these tumoral regions was separately scored by SSTR2 staining localization (membrane, cytoplasmic), overall staining intensity and local staining differences within each region. RESULTS: SSTR2 immunoreactivity was progressively weaker as the tumor cells advanced through the small intestinal layers. This was exemplified by a reduction in the amount of tumor samples with strong SSTR2 expression in the deeper histological levels of the section; 56% of tumors displayed strong SSTR2 expression in the mucosal region, as compared to 29% and 30% of tumors within muscularis propria and subserosal layers, respectively. CONCLUSIONS: This observation indicates a down-regulation of SSTR2 expression as the tumors progress through the intestinal wall, which might signify underlying biological processes of importance for SI-NET invasion behavior.
Ämnesord
- Medical and Health Sciences (hsv)
- Basic Medicine (hsv)
- Neurosciences (hsv)
- Medicin och hälsovetenskap (hsv)
- Medicinska och farmaceutiska grundvetenskaper (hsv)
- Neurovetenskaper (hsv)
Genre
- government publication (marcgt)
Indexterm och SAB-rubrik
- SI-NET; SSTR2; immunohistochemistry; invasion
Inställningar
Hjälp
Beståndsinformation saknas