Sökning: onr:4ds69v8922q7mj78 > Cetirizine per os
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Cetirizine per os [Elektronisk resurs] exposure and antihistamine effect in the dog
- Ekstrand, Carl (författare)
- Ingvast-Larsson, Carina (författare)
- Bondesson, Ulf (författare)
- Hedeland, Mikael (författare)
- Olsen, Lena (författare)
- Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (utgivare)
- Publicerad: BMC, 2018
- Engelska.
- Ingår i: Acta Veterinaria Scandinavica. - 1751-0147. ; 60
- E-artikel/E-kapitel
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- BackgroundCetirizine is an antihistamine used in dogs, but plasma concentrations in relation to effect after oral administration are not well studied. This study investigated cetirizine exposure and the plasma cetirizine concentration-antihistamine response relation in the dog following oral administration of cetirizine.ResultsEight Beagle dogs were included in a cross-over study consisting of two treatments. In treatment one, cetirizine 2-4mg/kg was administered per os once daily for 3days. The other treatment served as a control. Wheal diameter induced by intra-dermal histamine injections served as response-biomarker. Cetirizine plasma concentration was quantified by UHPLC-MS/MS. Median (range) cetirizine plasma terminal half-life was 10h (7.9-16.5). Cetirizine significantly inhibited wheal formation compared with the premedication baseline. Maximum inhibition of wheal formation after treatment with cetirizine per os was 100% compared with premedication wheal diameter. The median (range) IC50-value for reduction in wheal area was 0.33 mu g/mL (0.07-0.45). The median (range) value for the sigmoidicity factor was 1.8 (0.8-3.5). A behavioral study was also conducted and revealed no adverse effects, such as sedation.ConclusionThe results indicate that a once-daily dosing regimen of 2-4mg/kg cetirizine per os clearly provides a sufficient antihistamine effect. Based on this experimental protocol, cetirizine may be an option to treat histamine-mediated inflammation in the dog based on this experimental protocol but additional clinical studies are required.
Ämnesord
- Agricultural and Veterinary sciences (hsv)
- Veterinary Science (hsv)
- Medical Bioscience (hsv)
- Lantbruksvetenskap och veterinärmedicin (hsv)
- Veterinärmedicin (hsv)
- Medicinsk biovetenskap (hsv)
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- government publication (marcgt)
Indexterm och SAB-rubrik
- Anti-inflammatory
- Efficacy
- Pharmacodynamics
- Pharmacokinetics
- Potency
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