Parallel Changes in Harvey-Bradshaw Index, TNFα, and Intestinal Fatty Acid Binding Protein in Response to Infliximab in Crohn’s Disease [Elektronisk resurs]
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Al-Saffar, Anas 1969- (författare)
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Meijer, Carl Hampus (författare)
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Gannavarapu, Venkata Ram (författare)
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Hall, Gustav (författare)
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Li, Yichen (författare)
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Diaz Tartera, Hetzel O. (författare)
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Lördal, Mikael (författare)
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Ljung, Tryggve (författare)
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Hellström, Per M. 1954- (författare)
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Dominic-Luc, Webb (författare)
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Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (utgivare)
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Gastroenterology and Hepatology (medarbetare)
- Egypt Hindawi Publishing Corporation 2017
- Engelska.
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Ingår i: Gastroenterology Research and Practice. - 1687-6121. ; 1-8
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Sammanfattning
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- Intestinal fatty acid binding protein (I-FABP) indicates barrier integrity. Aims: determine if I-FABP is elevated in active Crohn's disease (CD) and if I-FABP parallels anti-TNF alpha antibody (infliximab) induced lowering of TNF alpha and Harvey-Bradshaw Index (HBI) as potential indicator of mucosal healing. I-FABP distribution along human gut was determined. Serum from 10 CD patients collected during first three consecutive infliximab treatments with matched pretreatment and follow-up samples one week after each treatment and corresponding HBI data were analyzed. I-FABP reference interval was established from 31 healthy subjects with normal gut permeability. I-FABP and TNF alpha were measured by ELISA; CRP was measured by nephelometry. Healthy tissue was used for I-FABP immunohistochemistry. Pretreatment CD patient TNF alpha was 1.6-fold higher than in-house reference interval, while I-FABP was 2.5-fold higher, which lowered at follow-ups. Combining all 30 infusion/follow-up pairs also revealed changes in I-FABP. HBI followed this pattern; CRP declined gradually. I-FABP was expressed in epithelium of stomach, jejunum, ileum, and colon, with the highest expression in jejunum and ileum. I-FABP is elevated in active CD with a magnitude comparable to TNF alpha. Parallel infliximab effects on TNF alpha, HBI, and I-FABP were found. I-FABP may be useful as an intestine selective prognostic marker in CD.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Gastroenterology and Hepatology (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Gastroenterologi (hsv)
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