Serum metabolomic biomarkers of dementia [Elektronisk resurs]

• Aims: This study compared serum metabolites of demented patients (Alzheimer's disease and vascular dementia) and controls, and explored serum metabolite profiles of nondemented individuals 5 years preceding the diagnosis. Methods: Cognitively healthy participants were followed up for 5-20 years. Cognitive assessment, serum sampling, and diagnosis were completed every 5 years. Multivariate analyses were conducted on the metabolite profiles generated by gas chromatography/time-of-flight mass spectrometry. Results: A significant group separation was found between demented patients and controls, and between incident cases and controls. Metabolites that contributed in both analyses were 3,4-dihydroxybutanoic acid, docosapentaenoic acid, and uric acid. Conclusions: Serum metabolite profiles are altered in demented patients, and detectable up to 5 years preceding the diagnosis. Blood sampling can make an important contribution to the early prediction of conversion to dementia. 

Ämnesord

Medical and Health Sciences  (ssif)

Clinical Medicine  (ssif)

Medicin och hälsovetenskap  (ssif)

Klinisk medicin  (ssif)

Genre

government publication  (marcgt)

Indexterm och SAB-rubrik

Memory

Early diagnosis

Alzheimer’s disease

Vascular dementia

Gas chromatography