Autism spectrum disorder and low vitamin D at birth [Elektronisk resurs] a sibling control study
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Fernell, Elisabeth (författare)
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Bejerot, Susanne, 1955- (författare)
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Westerlund, Joakim (författare)
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Miniscalco, Carmela (författare)
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Simila, Henry (författare)
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Eyles, Darryl (författare)
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Gillberg, Christopher (författare)
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Humble, Mats B., 1952- (författare)
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Örebro universitet Institutionen för hälsovetenskap och medicin (utgivare)
- Publicerad: 2015
- Engelska.
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Ingår i: Molecular Autism. - 2040-2392. ; 6
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- Relaterad länk:
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http://www.oru.se/ (Värdpublikation)
Sammanfattning
Ämnesord
Stäng
- Background : Insufficient vitamin D activity has attracted increasing interest as a possible underlying risk factor in disorders of the central nervous system, including autism. Methods : In this study, 25-hydroxyvitamin D (25(OH) D) was analysed in 58 Sweden-born sibling pairs, in which one child had autism spectrum disorder (ASD) and the other did not. The study group consisted of two representative samples; 47 Gothenburg sibling pairs with mixed ethnicities and 11 Stockholm sibling pairs with Somali background. 25(OH) D levels were analysed in the stored dried blood spots taken in the neonatal period for metabolic screening. Results : The collapsed group of children with ASD had significantly lower vitamin D levels (M = 24.0 nM, SD = 19.6) as compared with their siblings (M = 31.9 nM, SD = 27.7), according to a paired samples t-test (P = 0.013). The difference was-most likely-not only accounted for by a difference in season of birth between ASD and non-ASD siblings since the mean 25(OH)D levels differed with similar effect size between the sibling pairs born during winter and summer, respectively. All children with African/Middle East background, both the children with ASD and their non-ASD siblings, had vitamin D deficiency. Conclusions : The findings suggest that low prenatal vitamin D may act as a risk factor for ASD, however, there is a need for replication with larger samples. Future research should study whether or not adequate supplementation of vitamin D to pregnant women might lower the risk for ASD in the offspring.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Neurology (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Neurologi (hsv)
- Neurology (oru)
- Neurologi (oru)
Genre
- government publication (marcgt)
Indexterm och SAB-rubrik
- Autism spectrum disorder
- Vitamin D
- 25-hydroxyvitamin D
- Neonatal
- Dried blood spots
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