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Choline-phosphate cytidylyltransferase-alpha as a possible predictor of survival and response to cisplatin neoadjuvant chemotherapy in urothelial cancer of the bladder [Elektronisk resurs]

Hemdan, Tammer, 1974- (författare)
Turker, Polat (författare)
Malmström, Per-Uno (författare)
Segersten, Ulrika (författare)
Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (utgivare)
Publicerad: TAYLOR & FRANCIS LTD, 2018
Engelska.
Ingår i: Scandinavian journal of urology. - 2168-1805. ; 52:3, 200-205
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  • Objectives: The aim of this study was to test choline-phosphate cytidylyltransferase-alpha (CCT-alpha) protein as a biomarker for neoadjuvant cisplatin chemotherapy response in a bladder tumor setting. Materials and methods: A total of 238 patients with T2-T4 bladder cancer enrolled into two prior randomized trials comparing neoadjuvant cisplatin-based chemotherapy (NAC) plus cystectomy with cystectomy only (no-NAC) were used as discovery and validation cohorts. Protein expression was determined with immunohistochemistry and assessed with Histo (H)-scoring. Results: In the discovery cohort, comprising 61 patients, the survival ratio after NAC treatment for CCT-alpha-negative patients was significantly increased (p = 0.001) while there was no survival advantage in the CCT-alpha-positive patient group. Similarly, in the validation cohort with 177 patients, NAC treatment improved survival only in the CCT-alpha-negative group (p = 0.006). Although there was a tendency for a good NAC response with negative CCT-alpha status, the interaction variable between biomarker and treatment was not significant (p = 0.24). In the cystectomy-only group, patients with positive CCT-alpha expression had a better survival than CCT-alpha-negative patients. This prognostic effect of CCT-alpha expression remained significant after adjusting for well-known prognostic factors in a multivariate analysis. In a pooled database of both patient data sets, multivariate analyses showed CCT-alpha status as an independent factor for overall survival (p = 0.018; hazard ratio = 1.80, 95% confidence interval 1.11-2.93). Conclusion: CCT-alpha status was not predictive of outcome of NAC response; however, in the control group with cystectomy only it was found to have prognostic value. 

Ämnesord

Medical and Health Sciences  (hsv)
Clinical Medicine  (hsv)
Urology and Nephrology  (hsv)
Medicin och hälsovetenskap  (hsv)
Klinisk medicin  (hsv)
Urologi och njurmedicin  (hsv)

Genre

government publication  (marcgt)

Indexterm och SAB-rubrik

Biomarker
bladder cancer
choline-phosphate cytidylyl-transferase-alpha
predictive
prognostic
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