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Dynamic contrast-enhanced magnetic resonance imaging may act as a biomarker for vascular damage in normal appearing brain tissue after radiotherapy in patients with glioblastoma [Elektronisk resurs]

Fahlström, Markus (författare)
Fransson, Samuel (författare)
Blomquist, Erik (författare)
Nyholm, Tufve (författare)
Larsson, Elna-Marie (författare)
Umeå universitet Medicinska fakulteten (utgivare)
Publicerad: Sage Publications, 2018
Engelska.
Ingår i: ; 7:11
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  • Background Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a promising perfusion method and may be useful in evaluating radiation-induced changes in normal-appearing brain tissue. Purpose To assess whether radiotherapy induces changes in vascular permeability (K trans ) and the fractional volume of the extravascular extracellular space (V e ) derived from DCE-MRI in normal-appearing brain tissue and possible relationships to radiation dose given. Material and Methods Seventeen patients with glioblastoma treated with radiotherapy and chemotherapy were included; five were excluded because of inconsistencies in the radiotherapy protocol or early drop-out. DCE-MRI, contrast-enhanced three-dimensional (3D) T1-weighted (T1W) images and T2-weighted fluid attenuated inversion recovery (T2-FLAIR) images were acquired before and on average 3.3, 30.6, 101.6, and 185.7 days after radiotherapy. Pre-radiotherapy CE T1W and T2-FLAIR images were segmented into white and gray matter, excluding all non-healthy tissue. K trans  and V e  were calculated using the extended Kety model with the Parker population-based arterial input function. Six radiation dose regions were created for each tissue type, based on each patient’s computed tomography-based dose plan. Mean K trans  and V e  were calculated over each dose region and tissue type. Results Global K trans  and V e  demonstrated mostly non-significant changes with mean values higher for post-radiotherapy examinations in both gray and white matter compared to pre-radiotherapy. No relationship to radiation dose was found. Conclusion Additional studies are needed to validate if K trans  and V e  derived from DCE-MRI may act as potential biomarkers for acute and early-delayed radiation-induced vascular damages. No dose-response relationship was found. 

Ämnesord

Medical and Health Sciences  (hsv)
Clinical Medicine  (hsv)
Radiology, Nuclear Medicine and Medical Imaging  (hsv)
Medicin och hälsovetenskap  (hsv)
Klinisk medicin  (hsv)
Radiologi och bildbehandling  (hsv)

Genre

government publication  (marcgt)

Indexterm och SAB-rubrik

Dynamic contrast-enhanced magnetic resonance imaging
DCE-MRI
radiation therapy/oncology
radiation effects
normal-appearing brain tissue
glioblastoma
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