Startsida
Hjälp
Sök i LIBRIS databas

     

 

Sökning: onr:dpk7n331bjrztksm > Experimental therap...

Experimental therapies of malignant glioma [Elektronisk resurs] with emphasis on angiogenesis inhibition

Sandström, Maria, 1969- (författare)
Henriksson, Roger (preses)
Johansson, Mikael (preses)
Smits, Anja (opponent)
Umeå universitet Medicinska fakulteten (utgivare)
Publicerad: Umeå : Umeå universitet, 2008
Engelska 76
Serie: Umeå University medical dissertations, 0346-6612 0346-6612
Ingår i:
Läs hela texten
Läs hela texten
  • E-bokAvhandling(Diss. (sammanfattning) Umeå : Umeå universitet, 2009)
Sammanfattning Ämnesord
Stäng  
  • Malignant glioma consists of a group of diseases where the localisation and the nature of the disease makes treatment an extreme challenge. Two important biological features of malignant glioma cells are their infiltrative growth and their ability to induce angiogenesis. Glioma cells migrate extensively behind the blood-brain barrier and infiltrate the surrounding brain making radical treatment with surgery and radiotherapy almost impossible. The aims of this thesis were to investigate factors of importance for glioma cell migration and angiogenesis and to evaluate if an anti-angiogenesis approach alone or in combination with current treatment modalities could inhibit glioma growth. For this purpose we used the BT4C orthotopic rat glioma model and investigated treatment effects of the vascular endothelial growth factor (VEGF) receptor-2 and epidermal growth factor (EGF) receptor tyrosine kinase inhibitor ZD6474 alone or in combination with temozolomide or radiotherapy. Altered protein expression pattern after anti-angiogenesis treatment was measured using a mass-spectrometric proteomic method, followed by multivariate data-analysis. The tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), plasminogen activator inhibitor-1 (PAI-1), and VEGF showed altered temporal and spatial mRNA expression during glioma progression. In early stages of tumour progression the expression was found throughout the tumour while in later stages, the expression was more predominant in the invasive tumour border. ZD6474 in monotherapy significantly inhibited tumour growth in the BT4C glioma model. The effect was further enhanced when combined with radiotherapy or temozolomide. Using mass-spectrometric methods an altered protein expression pattern after ZD6474 treatment was observed implicating the possibility to use proteomic methods for finding predictive biomarkers for anti-angiogenesis treatment. In conclusion, this thesis demonstrates a co-expression of factors important for glioma growth and angiogenesis and that treatment with an angiogenesis inhibitor has additive effects on glioma growth when combined with radiotherapy and chemotherapy. Finally, an altered protein expression pattern after anti-angiogenesis treatment is evident and detectable. Hopefully this work will contribute to and encourage further research to reach a better understanding of how to combine and evaluate different treatment approaches in malignant glioma. 

Ämnesord

Medical and Health Sciences  (hsv)
Clinical Medicine  (hsv)
Cancer and Oncology  (hsv)
Medicin och hälsovetenskap  (hsv)
Klinisk medicin  (hsv)
Cancer och onkologi  (hsv)
MEDICINE  (svep)
Surgery  (svep)
Oncology  (svep)
MEDICIN  (svep)
Kirurgi  (svep)
Onkologi  (svep)

Genre

government publication  (marcgt)

Indexterm och SAB-rubrik

glioma
angiogenesis
VEGF
tyrosinekinaseinhibitor
ZD6474
plasminogenactivator
tPA
uPA
proteomics
Inställningar Hjälp

Titeln finns på 1 bibliotek. 

Övriga bibliotek (1)

Ange som favorit
Om LIBRIS
Sekretess
Blogg
Hjälp
Fel i posten?
Kontakt
Teknik och format
Sök utifrån
Sökrutor
Plug-ins
Bookmarklet
Anpassa
Textstorlek
Kontrast
Vyer
LIBRIS söktjänster
SwePub
Sondera
Uppsök

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - Nationella bibliotekssystem

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy