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Numerical Solution Methods in Stochastic Chemical Kinetics [Elektronisk resurs]

Engblom, Stefan, 1976- (författare)
Lötstedt, Per (preses)
Huisinga, Wilhelm (opponent)
Uppsala universitet Teknisk-naturvetenskapliga vetenskapsområdet (utgivare)
Uppsala universitet Teknisk-naturvetenskapliga vetenskapsområdet (utgivare)
Publicerad: Uppsala : Acta Universitatis Upsaliensis, 2008
Engelska 68
Serie: Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, 1651-6214 1651-6214
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  • E-bokAvhandling(Diss. (sammanfattning) Uppsala : Uppsala universitet, 2008)
Sammanfattning Ämnesord
  • This study is concerned with the numerical solution of certain stochastic models of chemical reactions. Such descriptions have been shown to be useful tools when studying biochemical processes inside living cells where classical deterministic rate equations fail to reproduce actual behavior. The main contribution of this thesis lies in its theoretical and practical investigation of different methods for obtaining numerical solutions to such descriptions. In a preliminary study, a simple but often quite effective approach to the moment closure problem is examined. A more advanced program is then developed for obtaining a consistent representation of the high dimensional probability density of the solution. The proposed method gains efficiency by utilizing a rapidly converging representation of certain functions defined over the semi-infinite integer lattice. Another contribution of this study, where the focus instead is on the spatially distributed case, is a suggestion for how to obtain a consistent stochastic reaction-diffusion model over an unstructured grid. Here it is also shown how to efficiently collect samples from the resulting model by making use of a hybrid method. In a final study, a time-parallel stochastic simulation algorithm is suggested and analyzed. Efficiency is here achieved by moving parts of the solution phase into the deterministic regime given that a parallel architecture is available. Necessary background material is developed in three chapters in this summary. An introductory chapter on an accessible level motivates the purpose of considering stochastic models in applied physics. In a second chapter the actual stochastic models considered are developed in a multi-faceted way. Finally, the current state-of-the-art in numerical solution methods is summarized and commented upon. 


Natural Sciences  (hsv)
Mathematics  (hsv)
Computational Mathematics  (hsv)
Naturvetenskap  (hsv)
Matematik  (hsv)
Beräkningsmatematik  (hsv)
Beräkningsvetenskap med inriktning mot numerisk analys  (uu)
Scientific Computing with specialization in Numerical Analysis  (uu)


government publication  (marcgt)

Indexterm och SAB-rubrik

stochastic models
chemical master equation
mesoscopic kinetics
Markov property
jump process
moment closure problem
spectral-Galerkin method
high dimensional problem
hybrid methods
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