Pyriproxifen and microcephaly [Elektronisk resurs] :an investigation of potential ties to the ongoing "Zika epidemic" /[Ian Cotgreave ...]

Av Ian Cotgreave, Ali Alavian Ghavanini, Ernesto Alfaro-Moreno, Åke Bergman, Karin Cederbrant, Anna Forsby, Jonas Förare, Åke Gustafsson, Heike Hellmond, Johan Lindberg, Diana Lupu, Ulf Norinder, Joelle Rüegg, Mandy Tang, Mattias Öberg, Henrik Kylin, Patrik Andersson, Zhang Jin, Ingvar Bergdahl, Kristina Jakobsson, Christian Lindh, Barbara Demeneix, Lisbeth Knudsen
As part of the Swetox mission to react to emerging concerns in chemical health and environmental safety, a preliminary litterature investigation was undertaken to gather all readily available scientific information on PPF with respect to safety assessment, in order to better understand potential links between chemical exposure and the devopment of microcephaly in affected areas. Therefore the contents of the report do not constitute an attempt at either questioning the use of existing regulatory data in the manner prescribed by international regulatory proceedures, or as a new risk assessment, based on the scientific information and concepts discussed. Here we report our findings, with particular emphasis on exisiting regulatory information, potential for lack of translation of results from regulatory animal testing to humans, lack of human exposure data and suggestions on plausible mode(s) of action of PPF in human neurodevelopmental adversities such as microcephaly.

http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-126096Sammanfattning och fulltext från Linköping University Electronic Press

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